• Product Name: 37450 Dynamic Foot Tactile Instrument
• Order number: tlyon000402
• Brand Name: Ugo Italy

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37450- Dynamic Foot Tactile Instrument

The dynamic plantar tactile instrument is used to automatically evaluate the "tactile sensation" of rodent plantar surfaces. It is similar to electronic tactile measurement (Electronic Von Frey) and plantar tactile measurement (Plantar Von Frey), but the difference is that it can record the duration and force of claw retraction.

The movable tactile stimulation device is placed on the sole of the experimental animal's foot, and the magnitude of force and the speed of force increase can be set according to the needs of the experimenter.

The tactile measurement kit (Von Frey) increases the force by adding a fine wire with a diameter of 0.05mm each time until the animal's paw twitches.

The new mode of dynamic plantar tactile sensor is:

A movable tactile stimulation device equipped with a stimulation wire and an adjustable angle mirror;

It is actually a microelectronic processing unit that provides digital display, internal data storage, data export with flash memory, and external printer;

Spacious experimental operation platform;

Modular animal cages with 3-12 compartments that can be freely combined.

characteristic	advantage
Automatic force application by the instrument	Maintain consistency in force application speed, direction, etc
The operator only needs to press the switch	Compared to using Von Frey testing, this experiment has a shorter time and the operators will not feel bored
The magnitude and increase of force can be pre-set	More parameters meet the experimental needs

Specifications:

Start:	Soft key
Adjustable force range:	0 - 50.0 g, Resolution of 0.5 g
Adjustable force increase rate:	1 - 50 s, Resolution of 1s
Focus on the range of wire movement;	12 mm
Experiment time:	LCD display with a resolution of 0.1s
Connect computer:	DELTA 9-pin connection cable
Power Supply: Specifications: Animal Cover:	85-264 VAC - 50-60Hz - 20 W max 85 x 40 x 40 cm 3, each 20x20x14 (h) cm
Net weight:	12.50 Kg.
Gross weight: Packaging specifications:	Approximately 21.50 Kg 98x49x47cm

enclosure:

37000-145：	Panel embedded thermal printer
57145： 37450-278 37100	Micro thermal printer Additional stimulation, perforated platform, and animal protection cover Two sets of Durham animal grippers for facial pain experiment

reference:

Literature mentioning dynamic plantar tactile instruments:

- R. Lu, A. Schmidtko: “Direct Intrathecal Drug Delivery in Mice for Detecting In Vivo Effects of cGMP on Pain Processing” Methods in Molecular Biology 1020: 215-221, 2013

- I.Q. Russe et alia: “Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception” Journal of Pain 2, 2013

- J. Btesh et alia: “Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia” J. Neuroscience 33 (21): 9184-9193, 2013

- V. Brá zda et alia: “Dynamic Response to Peripheral Nerve Injury Detected by In Situ Hybridization of IL-6 and its Receptor mRNAs in the Dorsal Root Ganglia is not Strictly Correlated With Signs of Neuropathic Pain” Molecular Pain 9(42), 2013

- V. Shunmugavel et alia: “Simvastatin Ameliorates Cauda Equina Compression Injury in a Rat Model of Lumbar Spinal Stenosis” J. Neuroimmune Pharmacology 8 (1): 274-286, 2013

- O. Coste et alia: “The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors” Behavioural Brain Research 234 (1): 121-128, 2012

- M.K. Boettger et alia: “Differential Effects of Locally and Systemically Administered Soluble Glycoprotein 130 on Pain and Inflammation in Experimental Arthritis” Arthritis Research & Therapy 12 (R140): 1-9, 2010

- A.L.M. Scott and M.S. Ramer: ” Schwann Cell p75NTR Prevents Spontaneous Sensory Reinnervation of the Adult Spinal Cord” Brain: 1-12, 2010

- M. Rosemann et alia: “Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3416insG Mice” Mamm Genome 21: 12-27, 2010- D. Piomelli et alia:” Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism”.Nature NSC, 2010

- L. Ramer et alia: "Rho-Kinase Inhibition Enhances Axonal plasticity and Attenuates Cold Hyperalgesia after Dorsal Rhizotomy" J. Neuroscience, 24 (48), 10796-10805, 2004

- E. Escribano et alia: "Rapid Human Skin Permeation and Topical Anaesthetic Activity of a New Amethocaine Microemulsion" Skin Pharmacol. Physiol., 18, 294-300, 2004

- G. Villetti et alia: "Antinociceptive Activity of the N-Methyl-D-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain" J. Pharmacol. Exper. Therap., 306, 804-814, 2003

- M. Isabel Aré valo et alia: "Thermal Hyperalgesia and Light Touch Allodynia After Intradermal Mycobacterium butyricum Administration in Rat" Inflammation, 27 (5), 293-299, 2003

Durham Holders for Orofacial Stimulation

- F.G. Garrett, P.L. Durham et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigemi­nal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 (4): 336- 344,2012

- F.G. Garrett, P.L. Durham et alia: “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 2010